Crystallization Facility

Structure Gallery

Here we present some of the protein structures recently elucidated using crystals grown at our protein crystallization platform:

Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles

Koehler et al. (2025)

Nat Struct Mol Biol

pdb entry: 8RBJ

Strand-Swapped SH3 Domain Dimer with Superoxide Dismutase Activity

Haege, Schwan et al. (2025)

ACS Cent Sci. 11 157-166

pdb entry: 9GGO

Structural and mechanistic insights into activation of human RNA ligase RTCB by Archease.

Gerber et al. (2024)

Nat Commun 15 2378

pdb entries: 8BTT, 8BTX, 8ODO, and 8ODP

Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.

Klein et al. (2024)

Nat Commun 15 716

pdb entry: 8ONX

Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.

Kubikova et al. (2023)

PNAS 120 e2304385120

pdb entries: 8OIJ and 8OIK

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.

Soni et al. (2023)

Nat Commun. 14 772

pdb entries: 7Q72, 7Q73, and 7Q74

Structural and functional characterization of the N-terminal acetyltransferase Naa50.

Weidenhausen et al. (2021)

Structure 29 413-425

pdb entries: 6YZZ and 6Z00

Structural basis of Naa20 activity towards a canonical NatB substrate.

Layer et al. (2021)

Commun Biol 4 2

pdb entry: 6ZMP

Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus.

Koromyslova et al. (2020)

J Virol. 94 e00660-20

pdb entries: 6XW4, 6XW5, 6XW6, and 6XW7

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.

Sloan et al. (2020)

Nat Commun. 11 2223

pdb entries: 6RY3, 6RYD, 6RYI, and 6RYL

The Arabidopsis Nα-acetyltransferase NAA60 locates to the plasma membrane and is vital for the high salt stress response.

Linster, Layer et al. (2020)

New Phytol. 228 554-569

pdb entries: 6TGX and 6TH0

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.

Zhang, Gese et al. (2020)

Nat Commun. 11 1504

pdb entry: 6SR6

Structural Basis of Nanobodies Targeting the Prototype Norovirus.

Ruoff et al. (2019)

J Virol. 93 e02005-18

pdb entries: 6H6Y, 6H6Z, 6H70, 6H71, and 6H72

Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.

Kilic et al. (2019)

Acta Cryst. D75 498-507

pdb entry: 6H24

DENR–MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.

Ahmed et al. (2018)

PLOS Biol 16 e2005160

pdb entry: 5ONS

Atomic Structure of the Murine Norovirus Protruding Domain and Soluble CD300lf Receptor Complex.

Kilic et al. (2018)

J Virol. 92 e00413-18

pdb entry: 5OR7

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones.

Kityk et al. (2018)

Mol Cell 69 227-237

pdb entry: 5NRO

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Kater et al. (2017)

Cell 171 1599-1610

pdb entries: 6EMF and 6EMG

Structure of Naa15/Naa10 bound to HypK-THB.

Weyer et al. (2017)

Nat Commun. 8 15726

pdb entries: 5NNP and 5NNR

9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.

Dodonova et al. (2017)

Elife 6 e26691

pdb entry: 5MU7

Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.

Rodrigues et al. (2017)

Nat Chem Biol. 13 290-294

pdb entries: 5LNS, 5LNT, 5LNU, 5LNV, 5LNW, and 5LNR

Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.

Weyer et al. (2017)

Nat Struct Mol Biol. 24 144-151

pdb entry: 5MB9

Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.

Gumiero et al. (2016)

Nat Commun. 7 13563

pdb entry: 5TKY

Structural analysis of bovine norovirus protruding domain.

Singh et al. (2016)

Virology 487 296-301

pdb entry: 5E6T

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.

Horn et al. (2015)

Nat Commun. 6 8875

pdb entries: 5E4W, 5E4X, and 2N88

Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins.

Staudacher et al. (2015)

Free Radic Biol Med. 85 228-236

pdb entry: 4D73

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.

Calvino et al. (2015)

Nat Commun. 6 6510

pdb entry: 5AFF

Structure of the complete bacterial SRP Alu domain.

Kempf et al. (2014)

Nucleic Acids Res. 42 12284-12294

pdb entries: 4WFL and 4WFM

SRP RNA remodeling by SRP68 explains its role in protein translocation.

Grotwinkel et al. (2014)

Science 344 101-104

pdb entry: 4P3F

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.

Leidig et al. (2013)

Nat. Struct. Mol. Biol. 20 23-28

pdb entries: 4GNI and 4GMQ

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.

Kityk et al. (2012)

Mol. Cell 48 863-874

pdb entry: 4B9Q

Synchronizing nuclear import of ribosomal proteins with ribosome assembly.

Kressler et al. (2012)

Science 338 666-671

pdb entries: 4GMN and 4GMO

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer et al. (2011)

Science 333 758-762

pdb entries: 3SJA, 3SJB, 3SJC, and 3SJD